This is so much better and easier than the complicated TAPI setup one my CRM products requires.
The only issue I have is that with a CRM called Zoho that uses Ajax (I believe, I'm not familiar with these things) , it doesn't detect the page changes.
I tried using Tampermonkey and waitForKeyElements.js to catch the number element, remove the skype link Zoho adds. Then I have to manually refresh the page for the FOP2 extension to recognize it. I'm not sure if there's a way to tell the extension to scan the page again without manually hitting F5.